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Publications

Primary Externalizing Consortium Paper

Karlsson Linnér, R., Mallard, T.T., Barr, P.B., Sanchez-Roige, S., Madole, J.W., Driver, M.N., Poore, H.E., de Vlaming, R., Grotzinger, A.D., Tielbeek, J.J., Johnson, E.C., Liu, M., Rosenthal, S.B., Ideker, T., Zhou, H., Kember, R.L., Pasman, J.A., Verweij, K.J.H., Liu, D.J., Vrieze, S., COGA Collaborators, Kranzler, H.R., Gelernter, J., Harris, K.M., Tucker-Drob, E.M., Waldman, I.D., Palmer, A.A., Harden, K.P., Koellinger, P.D., & Dick, D.M. (2021). Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience, 24(10), 1367-1376. https://doi.org/10.1038/s41593-021-00908-3

 

Prior to publishing the primary paper, the Externalizing Consortium posted the following pre-print available on bioRxiv

Karlsson Linnér, R., Mallard, T.T., Barr, P.B., Sanchez-Roige, S., Madole, J.W., Driver, M.N., Poore, H.E., Grotzinger, A.D., Tielbeek, J.J., Johnson, E.C., Liu, M., Zhou, H., Kember, R.L., Pasman, J.A., Verweij, K.J.H., Liu, D.J., Vrieze, S., COGA Collaborators, Kranzler, H.R., Gelernter, J., Harris, K.M., Tucker-Drob, E.M., Waldman, I., Palmer, A.A., Harden, K.P., Koellinger, P.D., & Dick, D.M. (2020). Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health. bioRxiv. doi: https://doi.org/10.1101/2020.10.16.342501

 

Follow-up Study Publications by the Externalizing Consortium

Choi, M., Poore, H., Brislin, S. J., Aliev, F., Zellers, S., Saunders, G., Salvatore, J.E., Vrieze, S., Harden, K.P., Palmer, A., Raevuori, A., Latvala, A., & Dick, D. (Under review). Associations Between a Genetic Liability Toward Behavioral Undercontrol and Externalizing Outcomes Spanning Toddlerhood Through Early Adulthood in ~17,000 Individuals from Five Developmental Cohorts.

Barr, P. B., Bigdeli, T. B., Meyers, J. L., Peterson, R. E., Sanchez-Roige, S., Mallard, T. T., Dick, D. M., Harden, K. P., Wilkinson, A., Graham, D. P., Nielsen, D. A., Swann, A. C., Lipsky, R. K., Kosten, T. R., Aslan, M., Harvey, P. D., Kimbrel, N. A., Beckham, J. C., & Million Veteran Program (MVP) Cooperative Studies Program (CSP) #572 (2024). Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort. JAMA psychiatry, 81(2), 188–197. https://doi.org/10.1001/jamapsychiatry.2023.4141

Tanksley, P.T., Brislin, S., Wertz, J., de Vlaming, R., Courchesne-Krak, N.S., Mallard, T.T., Raffington, L.T., Karlsson Linnér, R., Koellinger, P., Palmer, A.A., Sanchez-Roige, S., Waldman I., Dick, D.M., Moffitt, T.E., Caspi, A., & Harden, K.P. (Under review). Do Polygenic Indices Capture ‘Direct’ Effects on Child Externalizing Behavior? Within-family Analyses in Two Longitudinal Birth Cohorts.

Williams, C.M., Poore, H., Tanksley, P.T., Kweon, H., Courchesne-Krak, N.S., Londono-Correa, D., Mallard, T.T., Barr, P., Koellinger, P.D., Waldman, I.D., Sanchez-Roige, S., Harden, K.P., Palmer, A.A., Dick, D.M., & Karlsson Linnér, R. (2023). Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. Behavior Genetics, 53(5-6), 404-415. https://doi.org/10.1007/s10519-023-10152-z

Poore, H.E., Hatoum, A., Mallard, T.T., Sanchez-Roige, S., Waldman, I.D., Palmer, A.A., Harden, K.P., Barr, P.B., & Dick, D.M. (2023). A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders. Addiction Biology, 28(9), e13319. https://doi.org/10.1111/adb.13319

Brislin, S.J., Salvatore, J.E., Meyers, J.L., Kamarajan, C., Plawecki, M.H., Edenberg, H., Kuperman, S., Tischfield, J., Hesselbrock, V., Anokhin, A., Chorlian, D., Schuckit, M.A., Nurnberger, J., Bauer, L., Pandey, G., Pandey, A., Kramer, J.R., Chan, G., Porjesz, B., Dick, D.M., & COGA Collaborators. (2023). Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. Psychological Medicine, 1-11. https://doi.org/10.1017/S0033291723001174

Kuo, S. I., Poore, H.E., Barr, P. B., Chirico, I.S., Aliev, F., Bucholz, K. K., Chan, G., Kamarajan, C., Kramer, J. R., McCutcheon, V.V., Plawecki, M. H., & Dick, D. M. (2022). The Role of Parental Genotype in the Intergenerational Transmission of Externalizing Behavior: Evidence for Genetic Nurturance. Development and Psychopathology, 1-11. https://doi.org/10.1017/S0954579422000700

Aliev, F., Barr, P. B., Davies, A. G., Dick, D. M., & Bettinger, J. C. (2022). Genes regulating levels of ω‐3 long‐chain polyunsaturated fatty acids are associated with alcohol use disorder and consumption, and broader externalizing behavior in humans. Alcoholism: Clinical and Experimental Research, 46(9), 1657-1664. https://doi.org/10.1111/acer.14916

Barr, P. B., Driver, M. N., Kuo, S. I., Stephenson, M., Aliev, F., Karlsson Linnér, R., Marks, J., Anokhin, A. P., Bucholz, K., Chan, G., Edenberg, H. J., Edwards, A. C., Francis, M. W., Hancock, D. B., Harden, K. P., Kamarajan, C., Kaprio, J., Kinreich, S., Kramer. J., Kuperman, S., Latvala, A., Meyers, J. L., Palmer, A. A., Plawecki, M. H., Porjesz, B., Rose, R. J., Schuckit, M. A., Salvatore, J. E., & Dick, D. M. (2022). Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects Across Multiple Cohorts. Molecular Psychiatry, 27(11), 4633–4641. https://doi.org/10.1038/s41380-022-01801-6

Barr, P. B., Mallard, T. T., Sanchez-Roige, S., Poore, H. E., Karlsson Linnér, R., COGA Collaborators, Waldman, I. D., Palmer, A. A., Harden, K. P., & Dick, D. M. (2022). Parsing genetically influenced risk pathways: Genetic loci impact problematic alcohol use via externalizing and specific risk. Translational Psychiatry, 12(1), 420. https://doi.org/10.1038/s41398-022-02171-x

Kuo, S. I., Salvatore, J. E., Barr, P. B., Aliev, F., Anokhin, A., Bucholz, K. K., Chan, G., Edenberg, H. J., Hesselbrock, V., Kamarajan, C., Kramer, J. R., Lai, D., Mallard, T. T., Nurnberger, J. I., Jr, Pandey, G., Plawecki, M. H., Sanchez-Roige, S., Waldman, I., Palmer, A. A., Externalizing Consortium, & Dick, D. M. (2021). Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behavior Genetics, 51(5), 543-558. https://doi.org/10.1007/s10519-021-10067-7

 

Follow-up Study Publications Led by External Investigators

Martínez-Levy, G. A., Maya-Martínez, M., García-Marín, L. M., Díaz-Torres, S., Gómez, L. M., Benjet, C., Rentería, M. E., Cruz-Fuentes, C. S., & Rabinowitz, J. A. (2024). Associations of externalizing polygenic scores with externalizing disorders among Mexican youth. Journal of psychiatric research, 171, 346–353. https://doi.org/10.1016/j.jpsychires.2024.01.030

Bigdeli, T. B., Barr, P. B., Rajeevan, N., Graham, D. P., Li, Y., Meyers, J. L., Gorman, B. R., Peterson, R. E., Sayward, F., Radhakrishnan, K., Natarajan, S., Nielsen, D. A., Wilkinson, A. V., Malhotra, A. K., Zhao, H., Brophy, M., Shi, Y., O’Leary, T. J., Gleason, T., Przygodzki, R., … Harvey, P. D. (2024). Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder. Molecular psychiatry, 10.1038/s41380-024-02472-1. Advance online publication. https://doi.org/10.1038/s41380-024-02472-1

Lahey, B. B., Durham, E. L., Brislin, S. J., Barr, P. B., Dick, D. M., Moore, T. M., … & Kaczkurkin, A. N. (2024). Mapping potential pathways from polygenic liability through brain structure to psychological problems across the transition to adolescence. Journal of Child Psychology and Psychiatry. https://doi.org/10.1111/jcpp.13944

Niarchou, M., Sanchez-Roige, S., Reddy, I. A., Reese, T. J., Marcovitz, D., & Davis, L. K. (2024). Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records. Translational Psychiatry, 14(1), 20. https://doi.org/10.1038/s41398-023-02713-x

Gustavson, D. E., Morrison, C. L., Mallard, T. T., Jennings, M. V., Fontanillas, P., Elson, S. L., Palmer, A. A., Friedman, N. P., & Sanchez-Roige, S. (2023). Executive Function and Impulsivity Predict Distinct Genetic Variance in Internalizing Problems, Externalizing Problems, Thought Disorders, and Compulsive Disorders: A Genomic Structural Equation Modeling Study. Clinical Psychological Science, 0(0). https://doi.org/10.1177/21677026231207845

Wang, H., Cao, M., Xi, Y., Cao, W., Zhang, X., Meng, X., … & Wang, Y. (2023). Externalizing traits: Shared causalities for COVID-19 and Alzheimer’s dementia using Mendelian randomization analysis. PNAS nexus, 2(6), pgad198. https://doi.org/10.1093/pnasnexus/pgad198

Vrijen, C., Nolte, I., Oldehinkel, A., Veenstra, R., & Kretschmer, T. (2023). Genetic confounding in bullying research: Causal claims revisited. Development and Psychopathology, 1-12. https://doi.org/10.1017/S0954579423000445

Tielbeek, J. J., Uffelmann, E., Williams, B. S., Colodro-Conde, L., Gagnon, É., Mallard, T. T., Levitt, B. E., Jansen, P. R., Johansson, A., Sallis, H. M., Pistis, G., Saunders, G. R. B., Allegrini, A. G., Rimfeld, K., Konte, B., Klein, M., Hartmann, A. M., Salvatore, J. E., Nolte, I. M., Demontis, D., … Posthuma, D. (2022). Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. Molecular psychiatry, 27(11), 4453–4463. https://doi.org/10.1038/s41380-022-01793-3

Kretschmer, T., Vrijen, C., Nolte, I. M., Wertz, J., & Hartman, C. A. (2022). Gene–environment interplay in externalizing behavior from childhood through adulthood. Journal of Child Psychology and Psychiatry, 63(10), 1206–1213. https://doi.org/10.1111/jcpp.13652