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Publications

Primary Externalizing Consortium Paper

Karlsson Linnér, R., Mallard, T.T., Barr, P.B., Sanchez-Roige, S., Madole, J.W., Driver, M.N., Poore, H.E., de Vlaming, R., Grotzinger, A.D., Tielbeek, J.J., Johnson, E.C., Liu, M., Rosenthal, S.B., Ideker, T., Zhou, H., Kember, R.L., Pasman, J.A., Verweij, K.J.H., Liu, D.J., Vrieze, S., COGA Collaborators, Kranzler, H.R., Gelernter, J., Harris, K.M., Tucker-Drob, E.M., Waldman, I.D., Palmer, A.A., Harden, K.P., Koellinger, P.D., & Dick, D.M. (2021). Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience, 24(10), 1367-1376. https://doi.org/10.1038/s41593-021-00908-3

 

Prior to publishing the primary paper, the Externalizing Consortium posted the following pre-print available on bioRxiv

Karlsson Linnér, R., Mallard, T.T., Barr, P.B., Sanchez-Roige, S., Madole, J.W., Driver, M.N., Poore, H.E., Grotzinger, A.D., Tielbeek, J.J., Johnson, E.C., Liu, M., Zhou, H., Kember, R.L., Pasman, J.A., Verweij, K.J.H., Liu, D.J., Vrieze, S., COGA Collaborators, Kranzler, H.R., Gelernter, J., Harris, K.M., Tucker-Drob, E.M., Waldman, I., Palmer, A.A., Harden, K.P., Koellinger, P.D., & Dick, D.M. (2020). Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and health. bioRxiv. doi: https://doi.org/10.1101/2020.10.16.342501

 

Follow-up Study Publications by the Externalizing Consortium

Tanksley, P.T., Brislin, S., Wertz, J., de Vlaming, R., Courchesne-Krak, N.S., Mallard, T.T., Raffington, L.T., Karlsson Linnér, R., Koellinger, P., Palmer, A.A., Sanchez-Roige, S., Waldman I., Dick, D.M., Moffitt, T.E., Caspi, A., & Harden, K.P. (Under review). Do Polygenic Indices Capture ‘Direct’ Effects on Child Externalizing Behavior? Within-family Analyses in Two Longitudinal Birth Cohorts.

Williams, C.M., Poore, H., Tanksley, P.T., Kweon, H., Courchesne-Krak, N.S., Londono-Correa, D., Mallard, T.T., Barr, P., Koellinger, P.D., Waldman, I.D., Sanchez-Roige, S., Harden, K.P., Palmer, A.A., Dick, D.M., & Karlsson Linnér, R. (2023). Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. Behavior Genetics, 53(5-6), 404-415. https://doi.org/10.1007/s10519-023-10152-z

Poore, H.E., Hatoum, A., Mallard, T.T., Sanchez-Roige, S., Waldman, I.D., Palmer, A.A., Harden, K.P., Barr, P.B., & Dick, D.M. (2023). A Multivariate Approach to Understanding the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders. Addiction Biology, 28(9), e13319. https://doi.org/10.1111/adb.13319

Brislin, S.J., Salvatore, J.E., Meyers, J.L., Kamarajan, C., Plawecki, M.H., Edenberg, H., Kuperman, S., Tischfield, J., Hesselbrock, V., Anokhin, A., Chorlian, D., Schuckit, M.A., Nurnberger, J., Bauer, L., Pandey, G., Pandey, A., Kramer, J.R., Chan, G., Porjesz, B., Dick, D.M., & COGA Collaborators. (2023). Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood. Psychological Medicine, 1-11. https://doi.org/10.1017/S0033291723001174

Kuo, S. I., Poore, H.E., Barr, P. B., Chirico, I.S., Aliev, F., Bucholz, K. K., Chan, G., Kamarajan, C., Kramer, J. R., McCutcheon, V.V., Plawecki, M. H., & Dick, D. M. (2022). The Role of Parental Genotype in the Intergenerational Transmission of Externalizing Behavior: Evidence for Genetic Nurturance. Development and Psychopathology, 1-11. https://doi.org/10.1017/S0954579422000700

Barr, P. B., Driver, M. N., Kuo, S. I., Stephenson, M., Aliev, F., Karlsson Linnér, R., Marks, J., Anokhin, A. P., Bucholz, K., Chan, G., Edenberg, H. J., Edwards, A. C., Francis, M. W., Hancock, D. B., Harden, K. P., Kamarajan, C., Kaprio, J., Kinreich, S., Kramer. J., Kuperman, S., Latvala, A., Meyers, J. L., Palmer, A. A., Plawecki, M. H., Porjesz, B., Rose, R. J., Schuckit, M. A., Salvatore, J. E., & Dick, D. M. (2022). Clinical, Environmental, and Genetic Risk Factors for Substance Use Disorders: Characterizing Combined Effects Across Multiple Cohorts. Molecular Psychiatry, 27(11), 4633–4641. https://doi.org/10.1038/s41380-022-01801-6

Barr, P. B., Mallard, T. T., Sanchez-Roige, S., Poore, H. E., Karlsson Linnér, R., COGA Collaborators, Waldman, I. D., Palmer, A. A., Harden, K. P., & Dick, D. M. (2022). Parsing genetically influenced risk pathways: Genetic loci impact problematic alcohol use via externalizing and specific risk. Translational Psychiatry, 12(1), 420. https://doi.org/10.1038/s41398-022-02171-x

Kuo, S. I., Salvatore, J. E., Barr, P. B., Aliev, F., Anokhin, A., Bucholz, K. K., Chan, G., Edenberg, H. J., Hesselbrock, V., Kamarajan, C., Kramer, J. R., Lai, D., Mallard, T. T., Nurnberger, J. I., Jr, Pandey, G., Plawecki, M. H., Sanchez-Roige, S., Waldman, I., Palmer, A. A., Externalizing Consortium, & Dick, D. M. (2021). Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. Behavior Genetics, 51(5), 543-558. https://doi.org/10.1007/s10519-021-10067-7

 

Follow-up Study Publications by External Investigators

Niarchou, M., Sanchez-Roige, S., Reddy, I. A., Reese, T. J., Marcovitz, D., & Davis, L. K. (2024). Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records. Translational Psychiatry, 14(1), 20. https://doi.org/10.1038/s41398-023-02713-x

Vrijen, C., Nolte, I., Oldehinkel, A., Veenstra, R., & Kretschmer, T. (2023). Genetic confounding in bullying research: Causal claims revisited. Development and Psychopathology, 1-12. https://doi.org/10.1017/S0954579423000445

Kretschmer, T., Vrijen, C., Nolte, I. M., Wertz, J., & Hartman, C. A. (2022). Gene–environment interplay in externalizing behavior from childhood through adulthood. Journal of Child Psychology and Psychiatry, 63(10), 1206–1213. https://doi.org/10.1111/jcpp.13652